This 38 year-old patient came to us with chronic shoulder subluxation due to EDS, which resulted in severe thoracic outlet syndrome and complex regional pain syndrome due to stretch of the arm on the brachial plexus. We took a comprehensive approach to identify and treat all the EDS-associated conditions, including POTS, brain fog, MCAS, and chronic migraine. We addressed the Thoracic Outlet Syndrome by treated cervical facet hypermobility with prolotherapy and Xeomin for cervical dystonia. We began to address the shoulder subluxation with prolotherapy and physical therapy. Care is ongoing with incremental, consistent improvement in pain and functioning.